501 SOMATOMEDIN (Sm-C) in FETAL GROWTH

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Low somatomedin-C (Sm-C) concentrations measured by direct radioimmunoassay in patients with chronic renal failure.

Ten patients suffering from chronic renal failure and undergoing regular hemodialysis were tested immediately before and immediately after a 3-hour dialysis. Serum levels of immunoreactive Sm-C, estimated on unextracted non acidified serum at non equilibrium, were significantly lower than in normal controls and no consistent modifications were observed after dialysis.

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Somatomedin-A (Sm-A) bioactivity in serum and amniotic fluid as related to weight in the fetal pig.

Serum and amniotic fluid Sm-A bioactivity has been assayed in the fetal pig using a double labelling technique. 3H-thymidine activity was always higher in fetuses and lower in sows than 35S activity. 35SO4 uptake was not stimulated or was inhibited in about 30 p. 100 of the fetal sera. 3H-thymidine uptake was stimulated in all of them. There was a significant correlation (P less than 0.001) bet...

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Somatomedin-C as a fetal growth promoting factor and amino acid composition of cord blood in Japanese neonates.

A study was undertaken to determine the relationship of somatomedin-C as a growth promoting factor to amino acid composition of umbilical venous blood in relationship to fetal growth. In full term pregnancy somatomedin-C from cases with appropriate fetal growth was greater than those with fetal growth retardation. Within the physical parameters of the neonate only birth weight of appropriate fo...

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Chemiluminescence immunoassay for somatomedin C in serum.

To select the best tracer for use in a competitive immunoassay, we conjugated human somatomedin C (SmC) to various chemiluminescent compounds via two different synthetic pathways. Naphthylhydrazides and arylhydrazides, used as the labels, were incorporated via their imidate or their succinimide esters. Conjugating the carboxy terminal of (amino ethyl)ethyl-isoluminol to SmC via a succinimide li...

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Somatomedin C deficiency in Asian sisters.

Two sisters of Asian origin showed typical clinical and biochemical features of primary somatomedin C (SM-C) deficiency (Laron dwarfism). Abnormalities of SM-C binding proteins were observed, one sister lacking the high molecular weight (150 Kd) protein.

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ژورنال

عنوان ژورنال: Pediatric Research

سال: 1985

ISSN: 0031-3998,1530-0447

DOI: 10.1203/00006450-198504000-00531